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Hydrocodone, sold under brand names such as Vicodin and Norco among many others, is a semisynthetic opioid derived from codeine, one of the opioid alkaloids found in the opium poppy. Wikipedia
Formula: C18H21NO3
Onset of action: 10–20 minutes
Duration of action: 4–8 hours
Metabolism: Liver: CYP3A4 (major), CYP2D6 (minor)
Trade name: Vicodin, Norco, many others
Bioavailability: Oral: 70%

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What is hydrocodone use for ?

In the first place, hydrocodone is used to relieve severe pain. Next, hydrocodone is only used to treat people who are expected to need medication to relieve severe pain around-the-clock for a long time and who cannot be treated with other medications or treatments. Also, hydrocodone extended-release (long-acting) capsules or extended-release tablets should not be used to treat pain that can be controlled by medication that is taken as needed. Hydrocodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

This monograph only includes information about the use of hydrocodone alone. If you are taking a hydrocodone combination product, be sure to read information about all the ingredients in the hydrocodone-combination monograph and ask your doctor or pharmacist for more information.

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Hydrocodone comes as an extended-release (long-acting) capsule and an extended-release (long-acting) tablet to take by mouth. The extended-release capsule is usually taken once every 12 hours. The extended-release tablet is usually taken once daily. Take hydrocodone at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydrocodone exactly as directed by your doctor.

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Swallow the extended-release capsules or extended-release tablets one at a time with plenty of water. Swallow each capsule or tablet as soon as you put it in your mouth. Do not presoak, wet, or lick the extended-release tablets before you put them in your mouth.

Your doctor will probably start you on a low dose of hydrocodone and may gradually increase your dose, not more than once every 3 to 7 days if needed to control your pain. After your take hydrocodone for a period of time, your body may become used to the medication. If this happens, your doctor may increase your dose of hydrocodone or may prescribe a different medication to help control your pain. Talk to your doctor about how you are feeling during your treatment with hydrocodone.

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Do not stop taking hydrocodone without talking to your doctor. If you suddenly stop taking hydrocodone, you may experience withdrawal symptoms such as restlessness, teary eyes, runny nose, yawning, sweating, chills, hair standing on end, muscle pain, widened pupils (black circles in the middle of the eyes), irritability, anxiety, back or joint pain, weakness, stomach cramps, difficulty falling asleep or staying asleep, nausea, loss of appetite, vomiting, diarrhea, fast breathing, or fast heartbeat. Your doctor will probably decrease your dose gradually.

Can I Overdose on Hydrocodone?

It is entirely possible to overdose on Hydrocodone, even if it prescribed to you. You might feel you need to take more of the medicine if the pain is relatively intense, but this is considered abusing your prescription. High doses of Hydrocodone can affect each user differently based on body type, tolerance, and strength of the pills. One more pill than prescribed can cause a spiraling effect of symptoms from drowsiness to nausea to death.

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Indications for Hydrocodone

Management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.


Use lowest effective dose for shortest duration. Individualize. Give every 4–6hrs as needed. Initially 1–2 tabs of 5mg/300mg (max 8 tabs/day) or 1 tab of 7.5mg/300mg or 10mg/300mg (max 6 tabs/day). Renal or hepatic impairment: initiate at lower doses; monitor. Concomitant use or discontinuation of CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). Withdraw gradually by 25–50% every 2–4 days.

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Not established.


Significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus.

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Boxed Warning:

Addiction, abuse, and misuse. Life-threatening respiratory depression. Accidental ingestion. Neonatal opioid withdrawal syndrome. Cytochrome P450 3A4 interaction. Hepatotoxicity. Risks from concomitant use with benzodiazepines or other CNS depressants.

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What are the precautions or warnings of hydrocodone ?

Firstly, accidental exposure may cause fatal overdose (esp. in children). COPD, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression; monitor and consider non-opioid analgesics. Abuse potential (monitor). Increased risk of hepatotoxicity with acetaminophen doses >4g/day, alcohol abusers. More-so, underlying liver disease. Adrenal insufficiency. Head injury. Increased intracranial pressure, brain tumors; monitor. Seizure disorders. CNS depression. Impaired consciousness, coma, shock; avoid. Biliary tract disease. Furthermore, acute pancreatitis. Discontinue at the 1st sign of rash or any other hypersensitivity. Drug abusers. Renal or hepatic impairment. Reevaluate periodically. Avoid abrupt cessation. Elderly. Cachectic. Debilitated. Labor & delivery: not recommended. Nursing mothers: monitor infants.

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Pharmacological Class:

Opioid + analgesic.

What are the interactions of hydrocodone

Firstly, increased risk of hypotension, respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor. Above all, during or within 14 days of MAOIs: not recommended. Also, avoid concomitant other acetaminophen-containing products. Furthermore, risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected.

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More-so, avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and/or precipitate withdrawal symptoms. Potentiated by CYP3A4 inhibitors (eg, macrolides, azole antifungals, protease inhibitors). Furthermore antagonised by CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin). Also, may antagonize diuretics; monitor. More-so, aralytic ileus may occur with anticholinergics. Also, may cause false (+) urine test for 5-hydroxyindoleacetic acid. Buy Hydrocodone Online – Buy Hydrocodone – Hydrocodone for sale

What is the adverse reaction of hydrocodone ?

Firstly, Lightheadedness, dizziness, sedation, other CNS effects, nausea, vomiting; respiratory depression, severe hypotension, syncope, hepatotoxicity (overdosage); rare: serious skin or hypersensitivity reactions.

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What are the precautions of hydrocodone

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other opioids (such as hydromorphone, morphine, codeine); or if you have any other allergies. More-so, his product may contain inactive ingredients, which can cause allergic reactions or other problems. Also, talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), gallbladder disease, disease of the pancreas (pancreatitis).

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Also, this drug may make you dizzy or drowsy. More-so, alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Furthermore, avoid alcoholic beverages. Also, talk to your doctor if you are using marijuana (cannabis).

More-so, liquid products may contain sugar and alcohol. Furthermore, caution is advised if you have diabetes, alcohol dependence, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Also, ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

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Also, children may be more sensitive to the side effects of this drug, especially slow/shallow breathing.

Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. Also, it may harm an unborn baby. Also, discuss the risks and benefits with your doctor.

More-so, his medication passes into breast milk and may have undesirable effects on a nursing infant. Also, tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Above all, consult your doctor before breast-feeding.

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What are the affects of hydrocodone ?

To begin with, hydrocodone may cause side effects. Also, tell your doctor if any of these symptoms are severe or do not go away:

  • stomach pain
  • dry mouth
  • tiredness
  • headache
  • back pain
  • muscle tightening
  • difficult, frequent, or painful urination
  • ringing in the ears
  • difficulty falling asleep or staying asleep
  • foot, leg, or ankle swelling
  • uncontrollable shaking of a part of the body

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Furthermore, some side effects can be serious. More-so, if you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

  • chest pain
  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
  • nausea, vomiting, loss of appetite, weakness, or dizziness
  • inability to get or keep an erection
  • irregular menstruation
  • decreased sexual desire
  • swelling of your eyes, face, lips, tongue, or throat
  • hoarseness
  • changes in heartbeat
  • hives
  • itching
  • difficulty swallowing or breathing

Furthermore, hydrocodone may cause other side effects not mentioned above.

Lastly, if you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).


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