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What is Methadone?

Methadone, sold under the brand name Dolophine among others, is an opioid used for opioid maintenance therapy in opioid dependence, and for pain. Detoxification using methadone can either be done relatively rapidly in less than a month or gradually over as long as six months. Wikipedia

Molar mass: 309.445 g/mol
Formula: C21H27NO
Excretion: Urine, faeces
Bioavailability: 15-20% subcutaneous; 100% intravenous; 41–99% (by mouth)
Onset of action: Rapid
Trade name: Dolophine, Methadose, others

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What is methadone used for ?

This medication is used to treat severe ongoing pain (such as due to cancer). Methadone belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Methadone is used as an analgesic in chronic pain, often in rotation with other opioids. Due to its activity at the NMDA receptor, it may be more effective against neuropathic pain; for the same reason, tolerance to the analgesic effects may be less than that of other opioids.

This medicine would be used to treat addiction to opioids ( such as heroin ) as part of a standard therapy program . Methadone is a member of a school of drugs referred to as opioid ( narcotic ) analgesics . It will help reduce withdrawal signs and symptoms caused by stopping other opioids . Buy Methadone Online – Buy Methadone Wafers Online – Methadone

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Obtain this medicine by mouth as instructed by your medical professional. You could obtain this drug with or without meals . For those who have nausea, it might assist to take this medications with food. Inquire your medical professional or pharmacist regarding different ways to reduce nausea ( for example in lying position for one or two hours with as minor head motion as possible). Buy Methadone Online – Buy Methadone Wafers Online – Methadone

Study the Patient Info Booklet if made available from your own pharmacist before you begin utilising methadone and also every time you obtain a fill up. For those who have any specific inquiries, question a physician or pharmacist.

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Take this medication by mouth as directed by your doctor. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

Tend not to chew or even swallow the pills . Before using , dissolve the dosage in four ounces ( a hundred and twenty mililitters  ) of drinking water or an acidic fruit drink ( for example orange juice ) . Drink every bit of the combination instantly . When there is any medication left in the cup , include a tiny bit of liquid and also drink most of the mixture . You should not make a source ahead of time . Usually do not inject this drug .

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If you are taking this medication to treat moderate to severe pain, take it on a regular schedule as directed by your doctor, not as needed for sudden (breakthrough) pain. The dosage is based on your medical condition and response to treatment.

This drug could cause suppression responses , particularly if it is often used regularly for a long period or in higher doses . In this kind of instances , withdrawal signs or symptoms ( including restlessness , watering eyes , runny nose , nausea , sweating , muscle aches ) may perhaps take place in the event you all of a sudden quit using this medicines . To put a stop to abstaining sensations , your physician may well reduce your dosage gradually . Check with your doctor or pharmacist to get more detailed info , as well as report any kind of withdrawal reactions right away .

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Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Stopping methadone maintenance treatment has a high risk of return to opioid abuse. Ask your doctor or pharmacist for more details.

When this medication is use for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

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Although carefully monitored dosages of methadone are legally and medically acceptable, methadone is still an opioid agonist drug like heroin or opium. It’s important to recognize that, while methadone is a milder drug, it is still a narcotic with a high chance of addiction and dangerous side effects. When a person takes methadone in any form, they run the risk of experiencing a host of dangerous effects, which can cause both physical and psychological harm.

Short-term effects of methadone can include the following:

  • Feelings of euphoria.
  • Sedation.
  • Drowsiness.
  • Relaxation.

The effects of methadone are similar to heroin but less intense and longer-lasting (effects can last up to 24 hours, while heroin’s effects last approximately 2-3 hours).

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Common Side Effects of Methadone

You should tell your doctor if any of the following side effects become severe or don’t go away:

  • Constipation
  • Weakness
  • Headache
  • Nausea or vomiting
  • Loss of appetite
  • Weight gain
  • Stomach pain
  • Sore tongue
  • Dry mouth
  • Sweating
  • Flushing
  • Mood changes
  • Difficulty urinating
  • Vision problems
  • Decreased sexual desire or ability
  • Missed menstrual periods
  • Difficulty falling asleep or staying asleep

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Serious Side Effects of Methadone

You should call your doctor immediately or seek emergency medical help if you experience any of the following severe side effects:

  • Seizures
  • Itching, hives, or rash
  • Hoarseness
  • Pounding heartbeat
  • Severe nervousness or restlessness
  • Difficulty swallowing or breathing
  • Extreme drowsiness
  • Fainting
  • Hallucinations (seeing or hearing things that do not exist)
  • Swelling of the eyes, face, mouth, tongue, or throat


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